Snow could fall overnight on Wednesday and into Thursday morning, forecasters have warned.
The Met Office said there could be snow showers and accumulations of up to 6cm.
It has issued a yellow ‘be aware’ warning and drivers have been told to expect disruption.
The Met Office said: “A cold and increasingly showery northwesterly flow is expected to develop during Wednesday and last through Thursday.
“Accumulating snow is likely away from windward coastal districts, especially overnight. Across Northern England 3-6 cm could accumulate especially over high ground.
“Strong and gusty winds will likely accompany snow showers, and lead to significantly reduced visibility at times, difficult driving conditions and temporary blizzards over high ground.”